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Three types of recombinant human granulocyte colony-stimulating factor have equivalent biological activities in monkeys

[3] [4] Clinical trials have demonstrated substantial reductions in hemoglobin A1c (up to 2.5% reduction from baseline) and body weight (up to 20% reduction from baseline) in the SURPASS and SURMOUNT clinical trial programs

However, the best results often come from how the supplement is delivered rather than just the total milligrams on the label

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The risk of weight regain needs to be addressed, perhaps through individualized dose-tapering strategies, given the increasing popularity of these agents for weight loss and the high discontinuation rates