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Tirzepatide No - standard peptide handling Cagrilintide No - amyloid fibril risk State Light protection Tirzepatide Yes Cagrilintide Yes State Oral viable Tirzepatide No Cagrilintide No Both compounds share similar refrigerator windows

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Figure 5A,B confirm a stable photoluminescence of PLGA nanoparticles encapsulating DDA-GSH-AuNCs in PBS or DMEM (Dulbeccos Modified Eagle Medium) contains 10% FBS (fetal bovine serum) for 24 hours with comparable photoluminescence stability in water as a control