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The medication isn't wrong
Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): A double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial
Funding The research is financially supported by the Shuangchuang Ph.D award of Jiangsu Province (No.JSSCBS20211252), the initializing Fund of Xuzhou Medical University (No.D2020013), the National College Students of Innovation and Entrepreneurship Training Program in Jiangsu Province (No.202110313048Y) and the Natural Science Foundation of Jiangsu Higher Education Institutions of China (No.22KJB310021 and No.22KJB520040)
Since GLP-1 constipation is caused directly by the medication slowing gastric and intestinal motility, bowel function typically returns to baseline within 1-2 weeks of discontinuation
However, the levels of Carboxy-HGB varied inconsistently, resulting in a significant interaction
Some people experience GI discomfort and prefer taking it with meals
