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Spermidine and spermine are catabolized by spermidine/spermine N 1 -acetyltransferase 1 (also known as diamine acetyltransferase 1) encoded by the SAT1 gene (also identified as SSAT)
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Bbs5 / mice were characterized by hyperphagia, learning deficits, glucose/insulin intolerance, and disrupted metabolic hormones, phenocopying human BBS
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