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While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention

Int J Mol Sci (2013) 14(11):2151324

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Standard Dose 0.5 mg (500 mcg) Standard loading dose after initial tolerance