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Rigorous, adequately powered randomised controlled trials, with standardised background therapy, longitudinal biomarker sampling, and patient-reported outcomes, are now needed to determine efficacy, optimal candidates, and durability of response

Some patients report reduced dumping episodes while on Retatrutide, likely due to even slower gastric emptying

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Not every man on TRT needs HCG

The optimal target is 160 grams

However, the association between SGLT2-i and systemic RAAS activation is not straightforward