While there is debate about whether a human correlate to B1 cells exists, our group recently described a CD27 + IgM + CD24 hi MZ-like B cell population in the peripheral circulation of humans that produces IgM OSE and correlates with atheroprotection 132
Implications for employers: This study provides evidence that pharmaceutical manufacturers could make substantial profits selling these drugs at much lower costs in the US
Key Takeaways The FDA boxed warning on semaglutide medications is based on animal studies, and current human trial data does not confirm the same risk
7080 = very high risk 6070 = high risk 4060 = moderate below 40 = lower risk West Virginia ranks as the most at-risk state in the U.S., with the highest Awareness Gap Index score
We Need More Nuanced Conversations The current conversation around GLP-1 medications is often extremely polarized: They are portrayed as miracle cures People who use them are either idolized or criticized In reality, it is more complicated than either extreme
Hunger was generally mild to moderate (36/10), with transient increases when exposed to food stimuli