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Protein Folding and Disulfide Bonds In the endoplasmic reticulum, glutathione supports proper protein folding, especially through formation and rearrangement of disulfide bonds: It helps proteins achieve correct three-dimensional structure, which is essential for receptor binding and normal function

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Cani PD, Possemiers S, Van de Wiele T, et al

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Diabetologia 53 (1), 153159 (2010)