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American Headache Society

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Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL (TM))

doi: 10.3389/fcimb.2023.1142041 67 GuYZhouGZhouFLiYWuQHeHet al

| Concentration | BAC Water | Doses at 0.5mg | Doses at 1.0mg | |---------------|-----------|----------------|----------------| | 5mg/mL (recommended) | 1.0mL | 10 doses | 5 doses | | 2.5mg/mL | 2.0mL | 10 doses | 5 doses | **Best practice:** Use 1.0mL BAC water (5mg/mL)

This review focuses on the pleiomorphic clinical presentations and the genetic substrate of FIC and proposes a possible diagnostic and therapeutic work-up for this group of diseases, considering the shared factors and therapeutic novelties that may affect them