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Gastroenterology 162 , 11971209.e13 (2022)

Important Note: Seek urgent medical care for trouble breathing, swelling of the face or throat, widespread hives, dizziness, or symptoms that suggest a serious allergic reaction

They're remarkably effective at creating caloric deficits but don't directly enhance fat metabolism

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Increased risk for COVID19 breakthrough infection in fully vaccinated patients with substance use disorders in the United States between December 2020 and August 2021

Lifestyle modification remains foundational, though it requires intensive support to be effective long-term