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Here, we demonstrated consistent metabolic benefits of an oral, gut- and liver-restricted LXR inverse agonist, TLC-2716, in rodent, NHP and HLO models and, ultimately, in healthy human participants, supporting the potential of this approach for the treatment of cardiometabolic diseases

Integr.Cancer Ther 2006;5(1):83-89

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This formulation achieved 20.7% weight loss in trials, narrowing the gap between existing Ozempic/Wegovy and Retatrutide