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Consistent with the proposed mechanism of action, systemic application of an 2 -adrenergic receptor agonist abolished the stimulatory effect of GLP-1 in the OB on insulin secretion
The study has 176 clinical sites and an expected enrollment of 1,500 type 2 diabetic subjects randomized to weekly subcutaneous semaglutide and placebo
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Haghani, A
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Physical function improved significantly across all measures
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