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The combination was created to combine two independent satiety pathways in a single, weekly schedule

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[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head

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Serious concerns revolve around severe skin reactions and potential injury to the liver and kidneys

10.1016/j.neuint.2012.12.017 72 HuZ