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Functional indicators of oxidative stress included relative levels of 3-chlorotyrosine (3-CT), an established biomarker of a chronic inflammatory response, and aconitase activity, a biomarker of mitochondrial superoxide production

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The function of CDKN1A in cell cycle arrest, which is unable to trigger ferroptosis, is primarily achieved by binding to and suppressing the kinase activity of the cyclin-dependent kinases (CDKs) ( Interestingly, a recent study reported that retention of p53 in the nucleus, mediated by the interaction of long non-coding RNA (lncRNA) P53RRA, and Ras GTPase-activating protein-binding protein 1 (G3BP1), leads to cell cycle arrest, apoptosis, and ferroptosis

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Bmal1 KO adipocytes display a distinct pattern via downregulation of circadian rhythm, insulin signalling, glycerolipid metabolism and glutathione metabolism, with upregulation of thermogenesis, autophagy and cAMP signalling (Extended Data Fig