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Effects of mechanical stress stimulation on function and expression mechanism of osteoblasts
1 Introduction Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age, with a global prevalence ranging from 11% to 13% based on the Rotterdam diagnostic criteria ( Growing evidence suggests that the gut microbiome plays a fundamental role in maintaining host metabolic, immune, and endocrine homeostasis ( Building upon these pathophysiological insights, recent clinical investigations have identified distinct gut microbial signatures in PCOS patients, characterized by reduced -diversity and specific taxonomic alterations that correlate with key clinical features ( 2 The gut-ovary axis The gut microbiota and ovaries engage in sophisticated bidirectional crosstalk through an integrated network of metabolic, immunologic, and neuroendocrine pathways
Moreover, MAT2A can produce SAM, which trimethylates the promoter of ACSL3 , leading to ACSL3 upregulation and ferroptosis resistance in gastric cancer [71]
Oral acetylcysteine and the risk of age-related macular degeneration: A retrospective cohort study
Dermatology Practical & Conceptual , 8(1), 1521
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