Naltrexone/Bupropion: Nausea, constipation, headache, vomiting, and dizziness
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Gut bacteria ferment inulin to produce the corresponding metabolites
As Daniel Drucker's 2018 synthesis in Cell Metabolism sets out, the appetite effect and the gastrointestinal side effects come from the same mechanism
This overlap prevents a gap in receptor occupancy and keeps hunger signaling suppressed
Common side effects are nausea, vomiting, abdominal discomfort, diarrhea and constipation