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Non-pharmacological approaches form the foundation of ADHD management and include: Psychoeducation for patients and families about ADHD, its impact, and management strategies Environmental modifications such as structured routines, organisational aids, and minimising distractions Cognitive behavioural therapy (CBT) to address comorbid anxiety, depression, or low self-esteem Parent training programmes for children and adolescents with ADHD Occupational therapy to develop practical coping strategies Pharmacological treatment is recommended when ADHD symptoms cause significant impairment despite environmental modifications

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Conclusion: NFM, age-dependent maturation function, and GST enzyme activity may contribute to busulfan PK variability