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Melatonin activates two of the G-protein-coupled receptors: MT1 that regulates vigilance states of rapid eye movement (REMS), and MT2 that controls non-REMS

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In the brain, MAO-B converts it into a neurotoxin, MPP+, which can cause cell death in dopamine-producing neurons in the substantia nigra

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Likewise, assays of GCL and GS activity in the cytosol and chloroplast fractions of Arabidopsis leaf tissue show specific activities as follows: GCL cytosol 2.2 0.3 nmol min 1 mg total protein 1 (18% total activity) and GCL chloroplast 10.0 0.6 nmol min 1 mg total protein 1 (82% total activity)

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