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High insulin tells your body to store everything as fat and prevents access to stored energy

Overexpression of thioredoxin renders embryos more resistant to oxidative stress (Kobayashi-Miura et al., 2002), whereas thioredoxin null mutants exhibit dramatically reduced proliferation of the inner cell mass resulting in lethality during the early postimplantation period (reviewed in Ufer et al., 2010)

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ACS Chem Neurosci 13:486496

However, this was an observational study, so it does not establish causality, and GLP-1 agents should not yet be considered primary treatments for depression or anxiety, he told Healthline