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Physiologically, Fe + -bound transferrin (TF) is internalized via transferrin receptor 1 (TFR1), reduced to Fe + and transported by divalent metal transporter 1 (DMT1) into the labile iron pool (LIP) or ferritin ( + to trigger Fenton reaction, ROS production, LPO and ferroptosis
Woenckhaus C et al
Cancer Cell 2012
In contrast, Nrf2 activators, such as sulforaphane, have been found to prevent homocysteine- or hydrogen peroxide-induced cataract formation in human lens epithelial cells by increasing nuclear translocation of Nrf2 and expressions of cellular antioxidants, including catalase, superoxide dismutase, glutathione peroxidase, and glutathione
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