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Functions of the pentose phosphate pathway in normal and diseased conditions The Pentose phosphate pathway (PPP) is primarily energy forming, and non mitochondrial with only a cytoplasmic enzymatic presence entrusted to utilizing 6 carbon sugars, and producing in turn 5 carbon sugars for the synthesis of neucleotides, nucleic acids and reducing equivalents in the form of NADPH

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NNMT is highly expressed in the white adipose tissue of individuals with obesity and diabetes, where it acts as a "metabolic brake," slowing down the rate at which cells burn energy

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