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The molecule has been studied in animal models of adipose-tissue metabolism, with published preclinical work examining its effects on NAD+ pool dynamics and on the methyl-donor balance NNMT regulates

According to USDA Agricultural Research Service data based on NHANES, approximately 6% of adults aged 60 and older in the United States are vitamin B12 deficient, defined as plasma B12 below 148 pmol/L (2009)

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