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Manganese complexes displaying superoxide dismutase activity: a balance between different factors
The ratio between GSH: GSSG determines cell redox and is considered a valid marker of cellular toxicity The accumulation of GSSG due to oxidative stress is considered to be directly toxic to cells In a resting cell, the GSH: GSSG ratio typically exceeds 100:1, while in various models of oxidative stress, this ratio has been found to be as low as 10:1 and in some cases, even 1:1 Even marginal reductions in GSH may impair immune function and increase susceptibility to a wide range of toxins and oxidative damage
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Glutathione should not be offered from a drip bar, a mobile van or an unsupervised vitamin menu and it should never be marketed as a whitening agent
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Emerging evidence suggests glutathione may enhance macrophage function and improve pathogen clearance, supporting its role as an adjunct rather than a standalone therapy
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