You want the compound with the longest real-world safety record in this class (approved since 2017 as Ozempic, 2021 for weight management as Wegovy)
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Questions around affordability, access, long-term sustainability, and equitable coverage will likely determine how much impact these therapies ultimately have on population health
To this end, RGA developed a model to assess the potential impact of these drugs as treatments for weight loss in obese populations, and for diabetes on population mortality and morbidity, revealing significant potential reductions in cardiovascular incidence and mortality rates
But increased demand may increase prices when they are more widely available
Zhao M, Zhao L, Xiong X, He Y, Huang W, Liu Z, et al