Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al
293 In a mouse model of Barretts esophagus, feeding an HFD was observed to promote dysplasia and carcinogenesis by modulating the esophageal microenvironment and gut microbiome, thereby inducing inflammation and promoting stem cell proliferation
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We found a significant reduction in the GSH/GSSG ratio in the GR-deficient strain compared to the WT strain ( P = 0.0011), indicating severe oxidative stress (Figure 6A)