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Acknowledgments We thank Biorender.com for providing fundamental materials of the scheme figures (Figure 4A and Figure 6B)

The Role of Comprehensive Weight Management The most successful approach to weight loss with these medications involves comprehensive care that includes medical evaluation and ongoing monitoring, nutritional counseling and meal planning support, exercise programming tailored to individual abilities, behavioral health support for eating patterns and emotional factors, and regular follow-up to adjust treatment as needed

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A randomized, double-blinded, placebo-controlled trial of oral Polypodium leucotomos extract as an adjunct to sunscreen in the treatment of melasma