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These findings suggest that the internalization process occurs via invagination of vesicles containing the aggregates and this process does not affect the cell membrane integrity
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Several clinical scales such as CIOMS/RUCAM scale and Maria and Victorino criteria have been proposed to establish causal relationship between offending drug and liver damage
The equilibrium constants of the adenosine triphosphate hydrolysis and the adenosine triphosphate-citrate lyase reactions J Biol Chem 1973
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The longest of the trials (SURMOUNT-4) reported weight loss of -20.9% within 36 weeks and an additional -5.5% (total of -25.4%) within 88 weeks of administration [20]
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