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2 Challenges of developing an oral peptide therapy The oral administration of peptides is not a new concept, and the challenges faced are best illustrated by considering the failure to date to produce a marketable oral formulation of insulin since its discovery in 1921 [1, 2, 8, 40]
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doi: 10.3389/fphar.2022.878407 Received 18 February 2022 Accepted 09 May 2022 Published 22 June 2022 Volume 13 - 2022 Edited by Kunlin Zhang, Institute of Psychology (CAS), China Reviewed by Shih-Min Hsia, Taipei Medical University, Taiwan Matthias David, Charit University Medicine Berlin, Germany Updates Copyright 2022 Arip, Yap, Rajagopal, Selvaraja, Dharmendra and Chinnapan
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