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Among the 53 SLC25 proteins in human, the most well-characterized ones include adenine nucleotide carriers (ANTs) that exchange ADP for ATP to support cellular bioenergetics and UCP1 that is exclusively expressed in brown adipose tissue and dissipates proton motive force to generate heat
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Exogenous GH can create a more sustained, elevated level (a bleed), which poses a greater, more constant challenge to insulin sensitivity
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