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NICE recommendations for GLP-1 therapy include: For type 2 diabetes (NICE NG28): GLP-1 therapy should only be continued if there is a beneficial metabolic response (HbA1c reduction of 11 mmol/mol [1.0%] and weight loss of 3% of initial body weight at 6 months)
The product shouldn't be treated as medically equivalent to, or a substitute for, prescription treatment
Here is what a typical 6-week drug holiday timeline looks like based on pharmacokinetic data and clinical reports
doi: 10.3389/fphys.2018.00477 173 LuS
Common side effects of GLP-1s are gastrointestinal issues, including nausea, vomiting, diarrhea, dehydration, and constipation
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