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Key red flags include pregnancy (no safety data, so contraindicated), active cancer (caution due to growth effects), autoimmune disorders, or organ failure

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Signals cellular repair at the root, not cosmetic coverage on top

doi:10.1089/acm.2010.0716 Mills BJ, Richie JP Jr, Lang CA (1994) Glutathione disulfide variability in normal human blood

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This confirmed the role of oxidative stress in the pathogenesis of melasma