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The glucagon receptor arm the feature that distinguishes retatrutide from earlier-generation incretin compounds drives hepatic glucose metabolism, lipid oxidation, and energy expenditure effects, all absent from GLP-1 mono-agonists and dual GLP-1/GIP agonists

10.1080/088800199277489 3 ArcanP.BozkurtO.CavusogluD.GencpnarP.HaspolatS.DumanO.et al (2020)