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It is worthy to note that cardiovascular disease and kidney disease are closely interrelated [80] and diminished renal function is strongly associated with morbidity and mortality in heart failure patients [81]
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Morgan Stewart, Pharm.D., clinical associate professor at The University of Texas at Austin, offers guidance to help patients and providers make informed choices based on tolerance, effectiveness, and side effect management
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An additional contributing factor may lie in the different ratio of the expression of phospholamban and SERCA in the human atrium compared to the mouse atrium (Gombosova et al