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That resistance wont disappear on its own

Considering the complexity of crosstalk between signaling pathways, an unknown p70S6K independent mechanism might exist to promote cell survival, which is inhibited by the combination of IGF-1R and MEK1/2 inhibitors

Are you taking the right dosage

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This multi-organ system was employed for in vitro PK/PD analyses, enabling personalized drug response profiling and supporting the development of individualized therapeutic strategies for NF1 -mutant BC (Fig