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Clinical trials have shown that gastrointestinal issues are the most frequently reported side effects, with 15.8% of patients experiencing nausea, 8.5% experiencing diarrhea, and 7.3% reporting abdominal pain [17]

Furthermore, from a purely conceptual standpoint, one might postulate that metabolic reprogramming signals carried by these exosomes could disrupt the metabolic plasticity of recipient cells, blocking their adaptive transition from oxidative phosphorylation to glycolysis and thereby imprisoning cells in a metabolic phenotype highly sensitive to cuproptosis ( We must strongly emphasize that this exosome-mediated cuproptosis propagation network is currently entirely conceptual and lacks direct empirical evidence in ARDS models

Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure

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BMC Complementary and Alternative Medicine

DOI: 10.1073/pnas.2426564122