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Higher-order structure characterisation through techniques such as NMR, circular dichroism (CD), and FTIR Stability studies to assess degradation pathways including oxidation, deamidation, and oligomerisation Importantly, formulation components can interfere with detection (e.g., UV-active excipients), requiring careful method design and sample preparation strategies such as buffer exchange
Efficacy and safety of AmBisome in combination with sodium stibogluconate or miltefosine and miltefosine monotherapy for African visceral leishmaniasis: phase II randomized trial
Each patient should undergo individualized risk assessment before treatment initiation
It also i nteracts with multiple biologi cal pathways, providing cytoprotective, neuroprotective, and anti-inflammatory effects
Follow institutional biosafety and chemical-handling requirements
& Belforte, J
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