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10 M menadione, a concentration which has been shown to upregulate GPX3 transcription in an immortalized bronchial epithelial cell line 60 , consistently induced expression of both GPX3 and NQO1 in phLF while the effects in phBEC were more variable

Physiological implications of cysteine persulfidation The formation of persulfides in cysteines may induce changes in the properties of the original thiol in different ways

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Free radicals are unstable molecules that cause cell damage