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Next, homogenates were centrifuged at 10,000 g for 5 min at 4 C to obtain supernatants, which were stored at 20 C until use

Focus on fiber-rich foods, lean proteins, healthy fats and fermented foods

At 50% uptake, assuming a discontinuation rate of 15.5% as observed in the SOUL trial, the corresponding estimates were 59,332 MACE, 14,215 cardiovascular deaths, 41,744 nonfatal MIs, and 12,260 nonfatal strokes

A Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) enrolled 338 adults with obesity and reported mean body weight reductions of up to approximately 24% over 48 weeks at the highest dose studied (12 mg weekly)

Eur J Endocrinol (2013) 169(6):8859

The synergy between receptor pathways produces outcomes that none could achieve individually