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Lapaquistat was initially developed as an alternative cholesterol-lowering drug to statins, and progressed to several phase 3 clinical trials, including one where subjects were given low or high doses of the drug (equivalent to the low or high doses given to mice in our study), both of which effectively reduced plasma LDL-cholesterol 25

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Reeder, Anthony E

If your nausea is more severe or doesnt seem to be improving, talk to your healthcare provider to see if you need to adjust your dose.