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The energy provided by B12 can also reduce the fatigue-driven eating that often undermines caloric restriction

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Combine them, and you get synergistic effects that exceed what either approach achieves independently

Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems