Extensive research has indicated that the HGF-cMet pathway protects against oxidative stress by upregulating antioxidant proteins like superoxide dismutase and catalase and stimulating GSH biosynthesis (Gomez-Quiroz et al
Primary systemic carnitine deficiency Primary systemic carnitine deficiency is a rare, autosomal recessive disorder caused by mutations (including deletions) in the SLC22A5 gene coding for carnitine transporter protein OCTN2 (organic cation transporter novel 2) (33)
HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
Glutathione is compartmentalized throughout the cell, with 80-85% in the cytosol, 10-15% in mitochondria, and smaller amounts in the endoplasmic reticulum, nucleus, and peroxisomes
Direct engagement of peptides with the central polar network facilitates conformational transitions required for G protein coupling and activation
Recapitulating the human condition, SKO mice displayed significantly enlarged livers when compared to WT controls ( Figure 3A ) (30, 31, 36)