The primary reference is Raun and colleagues (Eur J Endocrinol, 1998), the paper that introduced the molecule and established the property it is known for
Factors Affecting the Cost Dosage & Concentration Higher doses cost more
According to NICE Clinical Knowledge Summaries and the British National Formulary , the standard treatment is intramuscular injections of 1,000 mcg (1 mg) hydroxocobalamin
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