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Pryor JT, Cowley LO, Simonds SE

When we eat a meal containing fat, the gallbladder contracts and releases a concentrated burst of bile into the small intestine

It mimics glucagon-like peptide-1 (GLP-1), a hormone that regulates blood sugar and appetite

However, in activated PSCs, liraglutide, a GLP-1R agonist, did not stimulate release of inflammatory cytokines/chemokines, however, it stimulated PSC proliferation, which was dependent on ERK activation

Authorization was required for 5% or fewer of beneficiaries until 2024, then by 2025, it was required for nearly 100% (Figure 1)

Most glutathione is found in the liver where it detoxifies many harmful compounds to be excreted through the bile