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Injury depth determines healing potential, superficial lesions potentially healing while deep lesions rarely repair spontaneously
If side effects are intolerable at any dose, the standard approach is to reduce back to the last tolerated dose and remain there for an additional four weeks before attempting escalation again
10.1523/JNEUROSCI.07-02-00604.1987 14
Common Cycling Protocol: 8 weeks daily at 12 mg/day 4 weeks off repeat
Changes in activity level, exercise habits, or overall health may influence body weight independently
Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems
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