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In trials, 5 mg weekly yielded roughly 15 percent average weight loss at 72 weeks, while 10 mg and 15 mg produced about 19.5 and 20.9 percent, respectively

28,36 Theoretically, the substitution of Gly 22 with Ala would make the -helix more stable, but increments in the affinity and activity were not found

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Scientific References Jastreboff, A

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