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[7] Published experience and post-marketing reports suggest that adverse reactions to topical GHK-Cu are uncommon and, when they occur, tend to be mild and localized

Intermediate Cu(II)-thiolate species in the reduction of Cu(II)GHK by glutathione: A handy chelate for biological Cu(II) reduction

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doi: 10.1038/nature07039

This peptide was also associated with a reduction in coarse wrinkles, and mottled pigmentation

The peptide operates through several identified mechanisms including upregulation of growth hormone receptors, activation of the FAK-paxillin pathway essential for cell migration, promotion of angiogenesis through VEGF modulation, and interaction with the nitric oxide system