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Studies show that a 4-fold increase in plasma GH produces a shift in fuel selection, with 29% more fat oxidation and 69% less carbohydrate oxidation, indicating enhanced metabolic flexibility
The strength of correlation between maximum CMAP amplitude and our primary outcome measure, the MHFMS, suggests that in non-ambulatory patients with SMA the CMAP may be a robust surrogate outcome measure for assessing treatment interventions if the putative mechanism of effect is to enhance innervated muscle mass by reinnervation or other trophic effects on nerve or muscle
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It is not yet fully understood what factors affect the integration of grafted astrocyte precursors and mature astrocytes
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