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In 1902, Bayliss and Starling made the first discovery of a hormone capable of stimulating pancreatic secretion, glucagon (Bayliss and Starling, 1902) (Figure 1B)

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However, semaglutide costs less ($199 compounded vs $349 for tirzepatide) and still provides excellent weight loss

10.1016/j.ygyno.2005.08.016 Gynecol

Locally delivered GLP-1 analogues liraglutide and exenatide enhance microvascular perfusion in individuals with and without type 2 diabetes