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This is evidenced by the negligible affinity of amylin or pramlintide for the isolated CTR ECD 19,20 , and by loss of affinity and/or potency of P32Y substituted CT peptides at the CTR 18,20

Understanding the role of DHT can help you see why these treatments are aimed where they are

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Higher doses of tirzepatide may allow for engagement of the mGIPR, but it remains unclear whether these high doses alter the effect of the ratio of GLP-1R:GIPR activity, potentially confounding the interpretation of results