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Cell culture studies In laboratory studies using 3T3-L1 adipocytes, a commonly used fat cell line, researchers found that 5-amino-1mq significantly reduced intracellular levels of 1-methylnicotinamide, confirming that it was successfully inhibiting NNMT

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Lipodystrophy study halted after patient death. NAM aidsmap , 31 July 2006

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These data suggest that Mecp2 -mediated let-7f upregulation leads to IGF-1 depletion in Rett syndrome, implicating let-7f as a potential therapeutic target for Rett syndrome

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